I have noticed two main issues playing with KB+M that mean I need to continually shift my keyboard hand around.
1. To loot, you need to click the item, click loot, then confirm the amount. A double-left click "loot all of this item" shortcut would be ideal.
2. The default stop-ship key is incredibly awkward; I mean it was in previous versions as well ("period" key), but while great for keyboard-only players, the down arrow is not an improvement in this respect. I realise it can be rebound (I used "z"), but maybe there should be two sets of default controls?